Osteoarthritis: The primary underlying cause of TKR is osteoarthritis, a degenerative joint condition that leads to muscular atrophy.
Arthritis: Inflammation of the knee joint, as well as other joints in the body.
Posttraumatic arthritis: Arthritis that develops following a severe knee injury or fracture.
Other conditions: Certain soft tissue ailments, knee deformities, and specific types of tumors may necessitate TKR.